- 1: Vaccine. (javascript:AL_get(this, 'jour', 'Vaccine.');) 2007 Jan 19; [Epub ahead of print] Links (javascript:PopUpMenu2_Set(Menu17280757);)
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17280757&query_hl=7&itool=pubmed_docsumNucleic acid-based antiviral drugs against seasonal and avian influenza viruses.
Antiviral Drugs And Avian Flu - a comprehensive view - Wellsphere::
Vaccine : Nucleic acid-based antiviral drugs against seasonal and With both seasonal and avian influenza virus developing increased resistance to both
http://www.wellsphere.com/wellpage/antiviral-drugs-and-avian-fluHOME |
Defence R&D Canada - Suffield, Ralston, AB, Canada.
<a href="#8">Legionnaires’ </a> <a href="#8">disease</a>::
File Format: PDF/Adobe Acrobata DNA chip based diagnostic test for P. aeruginosa,nucleic acid based .. identify the influenza viruses in sentinelrespiratory specimens are
http://www.eurosurveillance.org/images/dynamic/EQ/v04n01/v04n01.pdfHOME |
Influenza viruses are etiological agents of deadly flu that continue to pose global health threats, and have caused global pandemics that killed millions of people worldwide. The availability of neuraminidase inhibitors and attenuated vaccines improves our ability to defend against influenza, but their benefits can be significantly limited by drug-resistance and virus mutations. Nucleic acid-based drugs may represent a promising class of antiviral agents that could play a role in the prevention and treatment of influenza. Efficacy studies in animals have shown that ds RNA, such as poly ICLC can provide effective and broad-spectrum prophylaxis against lethal challenges against various strains of influenza A virus. Furthermore, similar level of antiviral protection in mice can be provided by using short fragments of oligonucleotides that induce antiviral immunity. Finally, influenza virus expression can also be specifically inhibited or suppressed using antisense oligonucleotides that bind to viral mRNA encoding key viral proteins. The versatility and potency of nucleic acid-based drugs make them potential drug candidates for used in seasonal or pandemic influenza situations.
OK, so how much money do they need for research+development
of these drugs, how likely will they work, what will they cost, when
could they be available ?
Comparing with the $10billion required by WHO for vaccine-
investment for the next 10 years
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